Despite Lincoln’s exoneration for his alleged crimes, the brothers’ freedom and happiness were short-lived as Michael was framed and sent to Sona Prison by “The Company,” the same government conspiracy that originally put Lincoln behind bars. Michael soon discovers that he was purposely placed in Sona to engineer another daring and seemingly impossible prison break – this time in order to free WHISTLER (Chris Vance), a mysterious inmate hiding within the prison’s sewer system.

Sona (inspired by the actual Carandiru Prison in Brazil) is unlike any American prison. A murderous riot among the inmates has driven all guards and authorities from the premises, leaving the prison with its own warped hierarchy and code of ethics created and ruled by vicious drug kingpin LECHERO (Robert Wisdom).

Once inside Sona, Michael must avert Lechero’s suspicions and wrath while protecting himself from a trio of enemies: ALEX MAHONE (William Fichtner), the renegade FBI agent who was revealed to be involved with The Company; BRAD BELLICK (Wade Williams), the former Fox River prison-guard-turned-hapless-bounty-hunter; and the one-handed, homicidal pedophile THEODORE “T-BAG” BAGWELL (Robert Knepper) – making Michael’s plans for escape even more difficult and complicated.

With the tables turned this time around, Lincoln must work outside the prison walls to help pull off the escape, as well as rescue his kidnapped son, LJ (Marshall Allman), and Michael’s true love, SARA TANCREDI (Sarah Wayne Callies). In Panama, Lincoln is reunited with fellow Fox River escapee FERNANDO SUCRE (Amaury Nolasco) and becomes involved with two beautiful women who will prove to be instrumental to the break – SUSAN B. ANTHONY (Jodi Lyn O’Keefe), a cool and deadly operative for The Company; and SOFIA (Danay Garcia), Whistler’s innocent girlfriend who is unaware of the danger she is about to encounter.

With the clock ticking, Michael and Lincoln must figure out a way to reunite with their loved ones, bring down The Company and engineer the most thrilling prison break yet.